Product name: Citicoline Sodium
Other name: Citicoline sodium Salt, CDP-Choline sodium; cytidine 5'-(trihydrogen diphosphate) p'-(2-(trimethylammonio)ethyl) ester inner salt monosodium salt; sodium5'-O-[({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphinato]cytidine
CAS NO.: 33818-15-4
Formula: C14H25N4NaO11P2
Molecular Weight: 510.31
EINECS NO.: 251-689-1
Appearance: White or off-white crystal powder
Solubility: Soluble easily in water, insoluble in ethanol,acetone and chloroform
Product description of Citicoline Sodium:
Citicoline Sodium is composed of ribose, cytosine, phosphoric acid and choline. As an endogenous compound, sodium cytidine choline is an important medium for the synthesis of phospholipids in cell membranes and an external source for the synthesis of acetylcholine, acetylcholine is an important neurotransmitter and plays an important role in nucleotide metabolis.
Citicoline Sodium can improve Hemiplegia caused by stroke can gradually restore the function of the limbs, and can also be used for other functional and conscious disorders caused by acute injury of the central nervous system, as well as for ischemic cerebrovascular disease and vascular dementia.
Specification Sheet of Citicoline Sodium:
| ITEM |
SPECIFICATION |
| Appearance |
White or off-white crystal powder
smell-less. |
Identification |
- Chemical reaction
- The retention time of a major peak meets the requirements.
- IR: Consistent with the spectrum obtained with reference substance.
4) Show sodium flame |
| Solubility |
Soluble easily in water, insoluble in ethanol,acetone and chloroform |
| Acid value |
Between 6.0-7.5 |
| Clarify and color of solution |
Clarifying,colorless |
| Chlorides |
≤0.05% |
| Ammonium |
≤0.05% |
| Iron |
≤0.01% |
| Phosphate |
≤0. 1% |
| Loss on drying |
≤6.0% |
| 5-CMP |
≤ 0.3% |
| The other largest impurities |
≤ 0.2% |
| The other total impurities |
≤ 0.7% |
| M-ethanol |
≤0.3% |
| E-thanol |
≤ 0.5% |
| Acetone |
≤ 0.5% |
| Heavy metals |
≤5ppm |
| Arsenic |
≤0.0001% |
| Endotoxin |
≤0.3EU/mg |
| Citicoline Sodium (Dry basis) |
≥98% |
| Packing |
Pack in paper-drums and two plastic bag inside. Net weight: 25kg/drum |
| Storage condition |
Store in a well closed place with constant low temperature and no direct sun light |
| Shelf life |
Two years when properly stored. |
Function of Citicoline Sodium:
Citicoline Sodium can improve the Consciousness disorders after acute craniocerebral trauma and brain surgery can gradually restore the function of limbs in hemiplegia caused by stroke, and can also be used in other central nervous system function and consciousness disorders caused by acute injury, and also used in ischemic cerebrovascular disease and vascular dementia.
1. Brain metabolic activators
2. Boost brain cell respiration
3. Improve circulation
4. Promoting arousal
5. Reducing cerebrovascular resistance
Clinical Applications of Citicoline Sodium:
Brain diseases; neurological disorder; Parkinson's disease; glaucoma.
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Company Profile:
* Our History:
Jingxin Nutra Co., Ltd focus on the development of R&D, manufacturing and exporting of nutrition & health ingredients since 2012. Our products are widely used in the fields of nutraceutical, dietary supplements, health food, beverage, cosmetic and pharmaceutical.
We have been proudly serving lots of contract manufacturers, brand customers and distributors in the global, and keeping very stable cooperation relationships with our customers.
* Main Market:
Europe, Russia, the Middle East, Asia, North America, South America etc. more than 50 countries and regions.
* Our Factory:
Our factory is constructed strictly in accordance with cGMP standard, it covers about 15000 square meters, with the clean workshop of 10000 square meters..
We have both production lines of plant extracts and chemicals.
-> Production lines of Plant Extracts:
We have 100,000 grade fine drying and packaging workshop to ensure that the products are not polluted.
• Extraction: It has a variety of extraction equipment, including multifunctional extraction, continuous countercurrent extraction, etc., which can be applied to the extraction of various medicinal materials, processing 8,000 tons of herb annually.
• Separation and refining: According to the product and process requirements, centrifugation, precision filtration, continuous ion exchange and other methods for separation and refining, to obtain high purity extract.
• Drying: With spray drying, freeze drying, vacuum drying, microwave drying.
-> Production lines of Chemicals:
It is based on enzyme catalysis technology to produce synthethic chemicals.The production lines are equipped with R&D center, pilot plant, chemical reaction workshop, biological fermentation workshop, clean workshop etc and meets production quality management of cGMP, FSSC22000 and HACCP.
* Main Products:
Glutathione, L-Theanine, L-Melatonin, Alpha Lipoic Acid , β-Nicotinamide mononucleotide (NMN), Coenzyme Q10, L-Carnitine Base, Selachyl alcohol, Beta Glucan, 3,3'-diindolylmethane (DIM), Ascorbic Acid (Vitamin C), Vitamin B12, Sweeteners etc.
Tongkat Ali Extract, Rutin, Fisetin, Milk Thistle Extract, Ginkgo Biloba Extract, Grape Seed Extract, Berberine HCL, Resveratrol, Monk Fruit Extract, Stevia Extract etc.
* Products Application:
Nutraceutical, dietary supplement, food additives, Beverage, cosmetics and feed additives etc.
* Certificates:
ISO, KOSHER, HALAL
* Quality Control:
We adhere to the orientation of 'Quality first" and strictly control the whole production process meet cGMP standard.
Our quality inspection center is equipped with physical and chemical room, Ultraviolet analysis room, Atomic absorption room, Atomic fluorescence room, Gas chromatography room, High Performance Liquid Chromatography room, balance room, High greenhouse, calibration room, bacteria examination room, Reagent room, stability laboratory, sample room and central laboratory.
The main testing capabilities include loss on drying, Ash, density, TLC, solubility, optical rotation, Transmittance, heavy metals, Lead, Arsenic, Calcium, Mercury, PH, protein, amino nitrogen, Assay, Purity, Solvent residue, Pesticide residue. Microbial detection includes detection of total Plate count, coliforms, yeasts and molds, salmonella, staphylococcus aureus etc.
We strictly test all products from source to finished products to ensure it meet customer's requirements.
* Our Service:
We provide raw material ingredients, Premix blend and OEM are avaliable too.
We have decades of the experience in these fields, could offer considerate, timely and professional service.
If the quality do not complies with customer's specification, we will undertake the responsibility and give customer a full refund.
We hope to be your long-term partner for mutual benefit.
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