Pharmaceutical Intermediate Synephrine Hydrochloride 99% Synephrine HCl

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP, Halal, ISO22000
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Model NO.: Synephrine HCL Synephrine Hydrochloride
• CAS No.: 5985-28-4
• Appearance: White to off-White Crystalline Powder
• Synonyms: Synephrine HCl
• Melting Point: 147-150°c
• Transport Package: 25kgs/Fiber Drum
• Specification: 99%
• Trademark: JX Nutra
• Origin: China
• HS Code: 2922509099
• Production Capacity: 5mt/Month

Product Description

Product name: Synephrine Hydrochloride 
CAS NO.: 5985-28-4
Assay: 99% (No less than 82% Synephrine)
Appearance: White to off-White crystalline powder
Molecular Formula:C9H14ClNO2
Molecular Weight: 203.67
Melting Point: 147-150°C
Synonyms: SYNEPHRINE HCL; Oxedrine hydrochloride; N-METHYL OCTOPAMINE HCL; Sympathol hydrochloride;Synephrine hydrochlorid;SYNEPHRINE HYDROCHLORIDE; (±)-Oxedrine hydrochloride
Export HS code: 2922509099


Specification Sheet:

Product Name:	Synephrine Hydrochloride
Country of Origin:	China	CAS No.	5985-28-4

                                                                                               

ITEM		SPECIFICATION	METHOD
Physical	Appearance	White to off-White crystalline powder	Visual
	Identification	IR spectrum	HPLC
	Particle size	98% pass 80mesh	Sieve
	Loss on drying	≤0.5%	2g/105ºC/5hrs
	Residue on ignition	≤0.5%	2g/800ºC/5hrs
Chemical	Heavy metals	≤10ppm	Colorimetric method
	Arsenic (As)	≤2ppm	Atomic Absorption
	Lead (Pb)	≤2ppm	Atomic Absorption
	Cadmium (Cd)	≤1ppm	Atomic Absorption
	Mercury (Hg)	≤1ppm	Atomic Absorption
Assay	Synephrine Hydrochloride	≥99%	HPLC
Microbial	Total Plate Count	≤1000CFU/g	ChP
	Yeast & Mold	≤100CFU/g	ChP
	E.Coli	Negative	ChP
	Salmonella	Negative	ChP
	Staphylococcus	Negative	ChP
Else	Packing	Pack in paper-drums and two food grade poly bags inside. Net weight: 25kg/drum
	Storage condition	Store in a well closed place with constant low temperature and no direct sun light
	Shelf life	Two years when properly stored.

Description:

Synephrine Hydrochloride is an alkaloid with vasoconstrictor and metabolic activities. It binds to α_1A-, α_2A-, and α_2C-adrenergic receptors (ARs; K_is = 78, 36.7, and 24.4 μM, respectively). Synephrine Hydrochloride is an agonist of α_1A-ARs in HEK293 cells (EC₅₀ = 4 μM in a reporter assay) but not in CHO cells expressing α_2A- or α_2C-AR. It also acts as an antagonist of α_1A-, α_2A-, and α_2C-ARs, inhibiting L-phenylephrine-induced activation of α_1A-AR in HEK293 cells and activation of α_2A- and α_2C-ARs induced by the α₂-AR agonist medetomidine in CHO cells (IC₅₀s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). Synephrine Hydrochloride induces contractions in isolated rabbit aortic rings (EC₅₀ = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (ynephrine Hydrochloride (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.
 

Usage: A α-adrenergic receptor agonist, vasoconstrictor.

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Company Profile:



* Our History:
Jingxin Nutra Co., Ltd focus on the development of R&D, manufacturing and exporting of nutrition & health ingredients since 2012. Our products are widely used in the fields of nutraceutical, dietary supplements, health food, beverage, cosmetic and pharmaceutical. 
We have been proudly serving lots of contract manufacturers, brand customers and distributors in the global, and keeping very stable cooperation relationships with our customers.

* Main Market:
Europe, Russia, the Middle East, Asia, North America, South America etc. more than 50 countries and regions.


* Our Factory:
Our factory is constructed strictly in accordance with cGMP standard, it covers about 15000 square meters, with the clean workshop of 10000 square meters..
We have both production lines of plant extracts and chemicals.

-> Production lines of Plant Extracts:
We have 100,000 grade fine drying and packaging workshop to ensure that the products are not polluted.
• Extraction: It has a variety of extraction equipment, including multifunctional extraction, continuous countercurrent extraction, etc., which can be applied to the extraction of various medicinal materials, processing 8,000 tons of herb annually.
• Separation and refining: According to the product and process requirements, centrifugation, precision filtration, continuous ion exchange and other methods for separation and refining, to obtain high purity extract.
• Drying: With spray drying, freeze drying, vacuum drying, microwave drying.

-> Production lines of Chemicals:
It is based on enzyme catalysis technology to produce synthethic chemicals.The production lines are equipped with R&D center, pilot plant, chemical reaction workshop, biological fermentation workshop, clean workshop etc and meets production quality management of cGMP, FSSC22000 and HACCP.



* Main Products:
Glutathione, L-Theanine, L-Melatonin, Alpha Lipoic Acid , β-Nicotinamide mononucleotide (NMN), Coenzyme Q10, L-Carnitine Base, Selachyl alcohol, Beta Glucan, 3,3'-diindolylmethane (DIM), Ascorbic Acid (Vitamin C), Vitamin B12, Sweeteners etc.

Tongkat Ali Extract, Rutin, Fisetin, Milk Thistle Extract, Ginkgo Biloba Extract, Grape Seed Extract, Berberine HCL, Resveratrol, Monk Fruit Extract, Stevia Extract etc.

* Products Application:
Nutraceutical, dietary supplement, food additives, Beverage, cosmetics and feed additives etc.

* Certificates:
ISO, KOSHER, HALAL

* Quality Control: 
We adhere to the orientation of 'Quality first" and strictly control the whole production process meet cGMP standard.

Our quality inspection center is equipped with physical and chemical room, Ultraviolet analysis room, Atomic absorption room, Atomic fluorescence room, Gas chromatography room, High Performance Liquid Chromatography room, balance room, High greenhouse, calibration room, bacteria examination room, Reagent room, stability laboratory, sample room and central laboratory.
The main testing capabilities include loss on drying, Ash, density, TLC, solubility, optical rotation, Transmittance, heavy metals, Lead, Arsenic, Calcium, Mercury, PH, protein, amino nitrogen, Assay, Purity, Solvent residue, Pesticide residue. Microbial detection includes detection of total Plate count, coliforms, yeasts and molds, salmonella, staphylococcus aureus etc.

We strictly test all products from source to finished products to ensure it meet customer's requirements.

* Our Service:
We provide raw material ingredients, Premix blend and OEM are avaliable too.

We have decades of the experience in these fields, could offer considerate, timely and professional service.

If the quality do not complies with customer's specification, we will undertake the responsibility and give customer a full refund.

We hope to be your long-term partner for mutual benefit.