High Quality Pterostilbene 99% Inhibit Skin Tumors Pterostilbene

• Powder: Yes
• Customized: Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Model NO.: Pterostilbene
• Product Name: Pterostilbene
• CAS No.: 537-42-8
• Appearance: off-White or White Powder
• Function: Anti Colon Cancer, Inhibit Skin Tumors
• Transport Package: 25kgs/Drum
• Specification: 99%
• Trademark: JX Nutra
• Origin: China
• HS Code: 2942000000
• Production Capacity: 5mt/Month

Product Description

Pterostilbene, 3',5'-Dimethoxy-4-stilbenol, 3,5-Dimethoxy-4'-hydroxy-E-stilbene, 3',5'-Dimethoxy-resveratrol, Pterostilbene


Product Name: Pterostilbene
CAS NO.: 537-42-8
Appearance: Off-white or white powder
Other names: 3',5'-Dimethoxy-4-stilbenol, 3,5-Dimethoxy-4'-hydroxy-E-stilbene, 3',5'-Dimethoxy-resveratrol
Molecular Formula: C16H16O3
Molecular Weight: 256.30

Pterostilbene Description: Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a stilbenoid chemically related to resveratrol. In plants, it serves a defensive phytoalexin role.
Pterostilbene its pharmacological effect is not only partially similar to resveratrol, but also has strong antifungal activity (its antifungal activity is five times that of resveratrol). The treatment of hyperlipidemia has a certain effect.

Natural occurrence:
Pterostilbene is found in almonds, various Vaccinium berries (including blueberries), grape leaves and vines,and Pterocarpus marsupium heartwood.
Safety and regulation: Pterostilbene is considered to be a corrosive substance, is dangerous upon exposure to the eyes, and is an environmental toxin, especially to aquatic life. A randomized, double-blind, placebo-controlled of healthy human subjects given pterostilbene for 6-8 weeks, showed pterostilbene to be safe for human use at dosages up to 250 mg per day.
Its chemical relative, resveratrol, received FDA GRAS status in 2007, and approval of synthetic resveratrol as a safe compound by the European Food Safety Authority (EFSA) in 2016. Pterostilbene differs from resveratrol by exhibiting increased bioavailability (80% compared to 20% in resveratrol) due to the presence of two methoxy groups which cause it to exhibit increased lipophilic and oral absorption.

Specification Sheet:

ITEM	SPECIFICATION	RESULT	STANDARD
Appearance	Off-white or white powder	Complies	Visual
Melting point	92~96ºC	94.1~94.9ºC	CP2015
Moisture content	≤0.5%	0.11%	Karl Fischer method
Residue on ignition	≤0.5%	0.15%	2g/800ºC/5hrs
Heavy metals	≤10ppm	Complies	href="javascript:void(0);" Colorimetric Method
Lead (Pb)	≤3ppm	Complies	Atomic Absorption
Arsenic (As)	≤2ppm	Complies	Atomic Absorption
Cadmium (Cd)	≤2ppm	Complies	Atomic Absorption
Mercury (Hg)	≤1ppm	Complies	Atomic Absorption
Purity	≥99%	99.16%	HPLC
Total Plate Count	≤1000CFU/g	<10CFU/g	ChP
Yeast &Mould	≤100CFU/g	<10CFU/g	ChP
Escherichia Coli	Negative	Negative	ChP
Salmonella	Negative	Negative	ChP
Packing	Pack in paper-drums and two food grade poly bags inside. Net weight: 25kg/drum (5kgs/Bag, 5Bags/Fiber drum)
Storage condition	Store in a well closed place with constant low temperature and no direct sun light
Shelf life	Three years when properly stored

                     

Application:
As an antioxidant, Pterostilbene can inhibit cell proliferation, reduce blood lipids, inhibit COX-1 and COX-2, anticancer and antifungal.
1. Colon Cancer 
Colon cancer is one of the most common malignant tumors, with the highest incidence in the age group of 40 to 50 years old. According to the world epidemiological survey, colon cancer is found to have the highest incidence in North America, Western Europe, Australia, New Zealand and other places, ranking second in visceral tumors, and the incidence and mortality in China are increasing year by year.
After years of experiments on animals, American scientists found that the compound extracted from blueberries and grapes can inhibit an enzyme called "P450 cytochrome", which can activate chemical carcinogens, and can reduce low-density lipoprotein cholesterol, so Pterostilbene has the function of preventing cancer and heart disease. Pterostilbene stilbene is a aromatic hydrocarbon called "styrene", which is a derivative of resveratrol. In the early 1990s, American scientists found that resveratrol has the function of preventing breast cancer and heart disease, and it is found in large quantities in red grape skin.
Pterostilbene stilbene helps prevent pre-cancer damage to the body. As an antioxidant and anti-inflammatory agent, it is found in both blueberries and blackberries. Ohio State University found that animals that ate raspberries were 80% less likely to develop colon cancer and 60% less likely to develop digestive tract tumors. German researchers found that drinking 2-3 cups of juice a day can also treat colon cancer.
According to statistics, after eight weeks of continuous consumption of blueberries or grapes containing Pterostilbene stilbene, the precancerous lesions in the colon were reduced by 57%. It reduces the spread of bowel cancer cells and suppresses certain genes that trigger inflammation, both of which are thought to be risk factors for colon cancer.

2. Inhibit Skin tumors

Skin tumors are one of the most common human tumors in the range. Epidemiological data show that UV radiation is the main carcinogen in skin tumors. UV irradiation stimulates the proliferation of abnormal skin cells, causing the cells to become cancerous through multiple signal transduction pathways. Many plant compounds, such as resveratrol and grape seed extract, have inhibitory effects on chemically induced skin tumors in mice. Modulating the survival of intermediate cell biomarkers by inhibiting epidermal hyperplasia and cell proliferation; Reduces inflammatory marker COX-2, oncogene mutation, and cell apoptosis to inhibit the development of skin tumors. Resveratrol can reduce skin papilloma induced by dimethylbenzanthracene/croton oil in mice by 60%, reduce the incidence of papilloma by prolongs the incubation period of tumor development, and reduce the number of tumors per mouse in a dose-dependent manner. By changing cell cycle, Pterostilbene stilbene inhibits the growth of cancer cells, induces cell apoptosis, and inhibits tumor growth and metastasis in vivo. In addition, Pterostilbene and resveratrol enhance the expression of antioxidant enzymes, such as heme oxygenase-1 and glutathione reductase, by significantly activating Nrf2. The death of tumor cells can also be induced by lysosomal membrane permeability. Due to its strong aggressiveness, early metastasis and high mortality, melanoma has become a malignant skin tumor. Radix santostilbene and quercetin inhibit the growth and metastasis of metastatic melanoma by inhibiting the expression of adhesion molecule-1 in rat hepatic sinus endothelial cells, thereby reducing the adhesion of B16M-F10 cells to endothelial cells, and inhibiting the expression of Bcl-2 in metastatic cells, thereby reducing the cytotoxicity of vascular endothelial cells. At the same time, the skin tumors induced by NF-κB and activator-protein-1 activation were significantly inhibited by sandalwood stilbene.
3. Anti-inflammatory
It is possible that by activating the reduced coenzyme oxidase through protein kinase C, the neutrophils are stimulated not to produce superoxide superoxide anion and myeloperoxidase, and the effects of the stilbene membranaceus decrease significantly at 100 μmol/L, so the effect of Stilbene membranaceus membranaceus may be dose-dependent. Astragalus has the ability to inhibit the activation of nuclear factor NF-κB, thereby inhibiting the activation of pro-inflammatory cytokines and nitric oxide synthase genes, resulting in decreased secretion of tumor necrosis factor α, interleukin1β, interleukin6 and nitric oxide, thereby reducing the inflammatory stimulus response.


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Company Profile:




* Our History:
Jingxin Nutra Co., Ltd focus on the development of R&D, manufacturing and exporting of nutrition & health ingredients since 2012. Our products are widely used in the fields of nutraceutical, dietary supplements, health food, beverage, cosmetic and pharmaceutical. 
We have been proudly serving lots of contract manufacturers, brand customers and distributors in the global, and keeping very stable cooperation relationships with our customers.

* Main Market:
Europe, Russia, the Middle East, Asia, North America, South America etc. more than 50 countries and regions.


* Our Factory:
Our factory is constructed strictly in accordance with cGMP standard, it covers about 15000 square meters, with the clean workshop of 10000 square meters..
We have both production lines of plant extracts and chemicals.

-> Production lines of Plant Extracts:
We have 100,000 grade fine drying and packaging workshop to ensure that the products are not polluted.
• Extraction: It has a variety of extraction equipment, including multifunctional extraction, continuous countercurrent extraction, etc., which can be applied to the extraction of various medicinal materials, processing 8,000 tons of herb annually.
• Separation and refining: According to the product and process requirements, centrifugation, precision filtration, continuous ion exchange and other methods for separation and refining, to obtain high purity extract.
• Drying: With spray drying, freeze drying, vacuum drying, microwave drying.

-> Production lines of Chemicals:
It is based on enzyme catalysis technology to produce synthethic chemicals.The production lines are equipped with R&D center, pilot plant, chemical reaction workshop, biological fermentation workshop, clean workshop etc and meets production quality management of cGMP, FSSC22000 and HACCP.



* Main Products:
Glutathione, L-Theanine, L-Melatonin, Alpha Lipoic Acid , β-Nicotinamide mononucleotide (NMN), Coenzyme Q10, L-Carnitine Base, Selachyl alcohol, Beta Glucan, 3,3'-diindolylmethane (DIM), Ascorbic Acid (Vitamin C), Vitamin B12, Sweeteners etc.

Tongkat Ali Extract, Rutin, Fisetin, Milk Thistle Extract, Ginkgo Biloba Extract, Grape Seed Extract, Berberine HCL, Resveratrol, Monk Fruit Extract, Stevia Extract etc.

* Products Application:
Nutraceutical, dietary supplement, food additives, Beverage, cosmetics and feed additives etc.

* Certificates:
ISO, KOSHER, HALAL

* Quality Control: 
We adhere to the orientation of 'Quality first" and strictly control the whole production process meet cGMP standard.

Our quality inspection center is equipped with physical and chemical room, Ultraviolet analysis room, Atomic absorption room, Atomic fluorescence room, Gas chromatography room, High Performance Liquid Chromatography room, balance room, High greenhouse, calibration room, bacteria examination room, Reagent room, stability laboratory, sample room and central laboratory.
The main testing capabilities include loss on drying, Ash, density, TLC, solubility, optical rotation, Transmittance, heavy metals, Lead, Arsenic, Calcium, Mercury, PH, protein, amino nitrogen, Assay, Purity, Solvent residue, Pesticide residue. Microbial detection includes detection of total Plate count, coliforms, yeasts and molds, salmonella, staphylococcus aureus etc.

We strictly test all products from source to finished products to ensure it meet customer's requirements.

* Our Service:
We provide raw material ingredients, Premix blend and OEM are avaliable too.

We have decades of the experience in these fields, could offer considerate, timely and professional service.

If the quality do not complies with customer's specification, we will undertake the responsibility and give customer a full refund.

We hope to be your long-term partner for mutual benefit.